Genomic Biology

Genomic Biology

Genomic Biology Review long as that information could be produced systemati-Roger Brent cally, by DNA sequencing projects, which were re-The Molecular Sciences Institute sources specialized for that purpose. During the middle 2168 Shattuck Avenue 1990s, a new term, functional genomics, came to refer Berkeley, California 94704 to generation and analysis of the information about what genes do, so...

Plasmodium Biology Genomic Gleanings

The highly A+T rich genomes of human and rodent malarial parasites offer unprecedented glimpses of a lineage that is distinct from other model organisms. Plasmodium is distinguished by the presence of numerous low complexity inserts within globular domains of proteins. It displays several peculiarities in its transcription apparatus, and its DNA repair system appears to favor a certain innate l...

The practical problems of post - genomic biology

describes the emergence of new postgenomic disciplines like proteomics, epigenomics, and phenomics. He proposes that integrated “omic” databases in the future will allow the in silico re-enacting of the entire organism once the totality of the information at the various levels, from genome to proteome and functions, is available. This is an attractive idea: just think of virtual organisms that ...

Complexity in post genomic biology Progress Report

Using Genomic Information to Understand Leishmania Biology

The genomes of different species of Leishmania have been deciphered in recent years. We learned that the genome content and organization of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar and annotation of these genomes revealed that there are few species-specific genes. Association of genome information with reverse and forward genetics approaches allows po...